In this study, we show that protein kinase C-induced TCR down.Įndoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?ĭirectory of Open Access Journals (Sweden)įull Text Available Phospholamban (PLN is an effective inhibitor of the sarco(endoplasmic reticulum Ca(2+-ATPase, which transports Ca(2+ into the SR lumen, leading to muscle relaxation. However, the role of the CD3γ diL motif in T-cell development is not known. In this study, we show that protein kinase C-induced TCR down-regulatio.The CD3γ di-leucine-based ( diL) receptor-sorting motif plays a central role in TCR down-regulation and in clonal expansion of virus-specific T cells. The CD3γ di-leucine-based ( diL) receptor-sorting motif plays a central role in TCR down-regulation and in clonal expansion of virus-specific T cells. Lauritsen, Jens Peter Holst Boding, Lasse Buus, Terkild B Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif
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